There really isn't a formation that gets more pressure on the QB than others, but from my experience the 4-3 gets the most pressure, but I have never really tried the 5-2 much, so maybe that gets the most pressure. I think that if you have fast defensive ends with high stamina and good agility then you will be able to get a lot of pressures on the opposing QB. You are probably wondering why I didn't include tackling, the reason why I didn't include it is because from my experience, tackling isn't really that important for a Defensive End. My best pass rusher that always puts pressure on the QB has a 3 in tackling, so tackling doesn't seem to matter much for a DE, at least my Defensive End.