Since the running game is completely useless above division V level, most people would focus on the Free Safety for pass protection (though you could argue that it doesn't really matter because the match engine just goes for Offensive shoot-outs irrespective of a team's D)

best players on the pitch, formation means absolutely nothing!!!! if the GE decides the other team will score when passing to his 1 dimensional receiver setup then nothing u put infront will change that.